Gabriella Gentile; Giancarlo Merlo; Alfonso Pozzan; Giovanni Bernasconi; Benjamin Bax; Paul Bamborough; Angela Bridges; Paul Carter; Margarete Neu; Gang Yao; Caroline Brough; Geoffrey Cutler; Aaron Coffinc; Svetlana L. Belyanskaya
Bioorg. Med. Chem. Lett., 2012, 22, 1989–1994
https://doi.org/10.1016/j.bmcl.2012.01.034

Abstract

5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.