5U9D - Discovery of a potent BTK inhibitor with a novel binding mode using parallel selections with a DNA-encoded chemical library

John W. Cuozzo; Paolo A. Centrella; Diana Gikunju; Sevan Habeshian; Christopher D. Hupp; Anthony D. Keefe; Eric A. Sigel; Holly H. Soutter; Heather A. Thomson; Ying Zhang; Matthew A. Clark
PDBJ - 5U9D
https://pdbj.org/mine/summary/5u9d

Abstract

Tyrosine-protein kinase BTK, (R)-N-methyl-2-(3-((quinoxalin-6-ylamino)methyl)furan-2-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide, 1,2-ETHANEDIOL

logo
logo