Cheng Cao; Peng Zhao; Ze Li; Zitian Chen; Yanyi Huang; Yu Bai; Xiaoyu Li
Chem. Commun., 2014, 50, 10997-10999
https://doi.org/10.1039/C4CC03380A

Abstract

We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.