N/A
Nat. Synth., 2023, 2, 1018–1019
https://doi.org/10.1038/s44160-023-00352-0

Abstract

The most popular reactions used by medicinal chemists are often incompatible with nanoscale ultrahigh-throughput experimentation (ultraHTE). Now, a set of ultraHTE-amenable reaction conditions is reported for four of the most important transformations in drug discovery, and their generality and scalability tested on a range of complex natural products and drug candidates.