Christoph E. Dumelin; Sabrina Trüssel; Fabian Buller; Eveline Trachsel; Frank Bootz; Yixin Zhang; Luca Mannocci; Susanne C. Beck; Mihaela Drumea‐Mirancea; Mathias W. Seeliger; Christof Baltes; Thomas Müggler; Felicitas Kranz; Markus Rudin; Samu Melkko; Jörg Scheuermann; Dario Neri
Angew. Chem. Int. Ed. Engl., 2008, 47, 3196-3201
https://doi.org/10.1002/anie.200704936

Abstract

Seeing eye to eye: Plasma‐protein binding is effective in improving the pharmacokinetic properties of otherwise short‐lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half‐life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture).