Wei Liu; Wei Deng; Saisai Sun; Chunyan Yu; Xubo Su; Aliang Wu; Youlang Yuan; Zhonglin Ma; Ke Li; Hongfang Yang; Xuanjia Peng; Justin Dietrich
Org. Lett., 2019, 21, 24, 9909-9913
https://doi.org/10.1021/acs.orglett.9b03843

Abstract

An efficient method is reported to synthesize sulfonamides on DNA from sulfinic acids or sodium sulfinates and amines in the presence of iodine under mild conditions. This method demonstrates a major expansion of scope of sulfonamide formation on DNA through the utilization of a novel sodium carbonate–sodium sulfinate bifunctional reagent class.