Matthew F. Calabrese
J. Med. Chem., 2025, 68(2), 1090–1091
https://doi.org/10.1021/acs.jmedchem.4c03091

Abstract

The Target 2035 initiative is an ambitious proposal to discover pharmacological tools across the human proteome. This Viewpoint summarizes an approach inspired by that goal leveraging DNA-encoded library coupled with machine learning approaches to assess the ligandability of the WD40 repeat target class of proteins.