Lik Hang Yuen; Raphael M. Franzini
ChemBioChem, 2017, 18(9), 829-836
https://doi.org/10.1002/cbic.201600567

Abstract

Discovery with DECLs: Encoding with DNA sequence barcodes enables rapid and inexpensive synthesis and interrogation of compound libraries of unprecedented size. Screening DNA‐encoded chemical libraries (DECLs) is increasingly used in drug discovery, with applications in chemical biology under development. This minireview summarizes key achievements in the field and analyzes its challenges and opportunities.
Abstract
DNA‐encoded chemical libraries (DECLs) are pools of DNA‐tagged small molecules that enable facile screening and identification of bio‐macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.