Yunyuan Huang; Yanxi Li; Jinrong Min
Trends Pharmacol. Sci., 2024
https://doi.org/10.1016/j.tips.2024.01.007

Abstract

The PWWP domain binds to both histone and DNA of a nucleosome in a bivalent way. PWWP domain-containing proteins are involved in different biological processes, and their aberrant expression is implicated in various human diseases. Here, we discuss the recent developments and challenges in targeting the PWWP domain for therapeutic intervention.