Liu Y; Sundah Nr; Ho Nry; Shen Wx; Xu Y; Natalia A; Yu Z; Seet Je; Chan Cw; Loh Tp; Lim By; Shao H
Nat. Biomed. Eng., 2024
https://doi.org/10.1038/s41551-024-01225-3

Abstract

Capturing the full complexity of the diverse hierarchical interactions in the protein interactome is challenging. Here we report a DNA-barcoding method for the multiplexed mapping of pairwise and higher-order protein interactions and their dynamics within cells. The method leverages antibodies conju …