Hongxin Zeng; Yanjing Li; Rongfeng Wu; Daqi Liu; Yang Zhang; Shiyang Xu; Dawen Niu
Org. Lett., 2023, XXXX, XXX, XXX-XXX
https://doi.org/10.1021/acs.orglett.3c00833

Abstract

Herein, we report a method that enables the synthesis of carbohydrate–DNA conjugates by radical addition. Key to the success is the use of readily available, bench-stable, and unprotected glycosyl sulfinates as precursors to glycosyl radicals. The redox neutral reaction proceeds under mild and simple conditions and tolerates a broad substrate scope. A small library of carbohydrate–DNA conjugates was prepared.