Hazem Salamon; Mateja Klika Škopić; Kathrin Jung; Olivia Bugain; Andreas Brunschweiger
ACS Chem. Biol., 2016, 11, 2, 296-307
https://doi.org/10.1021/acschembio.5b00981

Abstract

The identification of bioactive compounds is a crucial step toward development of probes for chemical biology studies. Screening of DNA-encoded small molecule libraries (DELs) has emerged as a validated technology to interrogate vast chemical space. DELs consist of chimeric molecules composed of a low-molecular weight compound that is conjugated to a DNA identifier tag. They are screened as pooled libraries using selection to identify "hits." Screening of DELs has identified numerous bioactive compounds. Some of these molecules were instrumental in gaining a deeper understanding of biological systems. One of the main challenges in the field is the development of synthesis methodology for DELs.