Jennifer Berger; Michael Oberhuber
Chem. Biodivers., 2010, 7, 2581-2615
https://doi.org/10.1002/cbdv.201000108

Abstract

In this review, we will focus on chemistry that is controlled by a NA templating effect without requiring a macromolecular catalyst. The possibilities that NAs offer to promote and control the formation (and rarely cleavage) of chemical bonds will be presented and discussed. Particular attention will be devoted to the added value of NAs for chemistry, since several excellent reviews on NA templating have been published in recent years [9 – 12]. In the tradition of chemical biology [13], we will discuss how the biological principles that are inherent to NAs can be used to advance chemistry, which, in turn, fuels advances in biology. Most examples will concern DNA templates, but RNA and some NA analogs will also be treated.