Kuo‐Ting Huang; Katarzyna Gorska; Susana Alvarez; Sofia Barluenga; Nicolas Winssinger
ChemBioChem, 2011, 12(1), 56-60
https://doi.org/10.1002/cbic.201000567

Abstract

Complex glycan arrays: A general method for preparing thioglycosides from native oligosaccharides and coupling them to peptide nucleic acids (PNAs) is reported. An array of 625 glycans was assembled by hybridization of two PNA‐encoded libraries of 25 glycan fragments. The cooperativity of the fragment for carbohydrate binding proteins was validated with lectins of known specificity.