Yusong Ye; Madeline Berry; William J. Bock; Kunpeng Cheng; Sajiv K. Nair; Christiana S. Park; Ryan L. Patman; Sylvie Sakata; Michelle Tran-Dubé; Joyann S. Donaldson; Guanyu Yang; Guansai Liu
Org. Lett. 2024, 26, 16, 3338–3342
https://doi.org/10.1021/acs.orglett.4c00604

Abstract

Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C–H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.