Wenting Wu; Zhen Sun; Xuan Wang; Xiaojie Lu; Dongcheng Dai
Org. Lett., 2020, 22, 8, 3239-3244
https://doi.org/10.1021/acs.orglett.0c01016

Abstract

An efficient and facile formal [4 + 2] cycloaddition reaction was developed to synthesize diverse thiazole-fused dihydropyrans (TFDP) on DNA. Mild reaction conditions, broad substrate scope, and compatibility with subsequent enzymatic ligation demonstrated the utility of this methodology in DNA-encoded library synthesis.