Zhaomei Sun; Lingqian Xiao; Yahui Chen; Jiangying Wang; Fanming Zeng; Huanqing Zhang; Jie Zhang; Kexin Yang; Yunjin Hu
ACS Med. Chem. Lett., 2023, 14(4), 473-478
https://doi.org/10.1021/acsmedchemlett.3c00022

Abstract

Organophosphonic compounds are distinctive among natural products in terms of stability and mimicry. Numerous synthetic organophosphonic compounds, including pamidronic acid, fosmidromycin, and zoledronic acid, are approved drugs. DNA encoded library technology (DELT) is a well-established platform for identifying small molecule recognition to target protein of interest (POI). Therefore, it is imperative to create an efficient procedure for the on-DNA synthesis of α-hydroxy phosphonates for DEL builds.