Animesh Roy; Thomas Kodadek
Trends Pharmacol. Sci., 2020, 41(4), 225-227
https://doi.org/10.1016/j.tips.2020.01.007

Abstract

DNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.