Adam P. Silverman; Eric T. Kool
Chem. Rev., 2006, 106, 9, 3775-3789
https://doi.org/10.1021/cr050057+

Abstract

The aim of this review is to summarize recent advances in the development of chemical reactions that are triggered by hybridization of an oligonucleotidesa synthetic short strand of DNAsto a target RNA or DNA strand and outline how these reactions are being used, or could be used, in detecting and identifying such targets in a biological sample or cell. First, we will briefly discuss the basic principles of DNA and RNA molecular recognition that underlie this research. We will then outline the historical development of such templated reactions and then proceed to delineate the current state of the art. Finally, we will predict some future areas of special promise and mention some exciting new technologies that are under development in this field.