Yizhou Li; Mingda Zhang; Chi Zhang; Xiaoyu Li
Chem. Commun., 2012, 48, 9513-9515
https://doi.org/10.1039/C2CC35230C

Abstract

A system capable of performing both DNA-templated chemical reactions and detection of bond formations is reported. Photocleavable DNA templates direct reactions. Products from bond-forming events re-ligate original templates, amplifiable by PCR, therefore distinguishing bond formation from background. This system provides a novel approach for discovering potential new chemical reactions.