Wentao Liu; Wei Huang; Qian Lin; Mei-Hsuan Tsai; Rui Zhang; Lijun Fan; Jack D. Scott; Guansai Liu; Jinqiao Wan
Bioorg. Med. Chem., 2021, 116118
https://doi.org/10.1016/j.bmc.2021.116118

Abstract

A robust palladium-catalyzed hydroxycarbonylation of aryl halides on DNA has been developed. Instead of Mo(CO)6 as a source of carbon monoxide as previously described in the literature, chloroform was used as a surrogate in this report for the purpose of avoiding to use a large excess of molybdenum reagent which is not totally soluble in aqueous reaction mixtures.