Lijun Xue; Sufang Zhou; Jing Wu; Nicolas Duchemin; Bingxin Chen; Jie Zhang; Huanqing Zhang; Kexin Yang; Yuniin Hu
Chembiochem, 2023, e202300206
https://doi.org/10.1002/cbic.202300206

Abstract

Here, we describe a novel method for the on-DNA synthesis of cyclic imides, an important class of molecules that includes several well-known medications. Significantly, the new method enabled on-DNA synthesis under mild conditions with high conversions and a broad functional group tolerance, utilizing ubiquitous bifunctional amines and bis-carboxylic acid, or alkyl halides, and therefore served as the linchpin for DEL synthesis. The mechanism study of off-DNA and on-DNA chemical transformations revealed unique insights in contrast to conventional chemical transformation.