Yiran Huang; Yuqing Deng; Jianfu Zhang; Ling Meng; Xiaoyu Li
Chem. Commun., 2021, 57, 3769-3772
https://doi.org/10.1039/D1CC00961C

Abstract

Membrane proteins are important drug targets; however, ligand discovery for membrane proteins is highly challenging due to their hydrophobic nature. We show that membrane proteins may be specifically labelled with a DNA tag by DNA-programmed affinity labelling (DPAL), thereby enabling the screening of chemical compounds against membrane proteins directly on live cells.