Christopher T. Calderone; James W. Puckett; Zev J. Gartner; David R. Liu
Angew. Chem. Int. Ed. Engl., 2002, 41(21), 4104-8
https://www.ncbi.nlm.nih.gov/pubmed/12412096

Abstract

Diversification without spatial separation can be achieved using DNA-templated synthesis. Twelve reactants with functional groups of similar reactivity linked to different DNA sequences (R, R′) were subjected to several different reaction types within the same solution and only six sequence-programmed products out of the more than 28 possibilities were formed (see scheme).