Jean-Pierre Daguer; Mihai Ciobanu; Sofia Barluenga; Nicolas Winssinger
Org. Biomol. Chem., 2012, 10, 1502-5
https://doi.org/10.1039/C2OB06880J

Abstract

Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.