Paul Edwards
Drug Discov. Today, 2010, 15, 15–16, 690-691
https://doi.org/10.1016/j.drudis.2010.06.013

Abstract

Medicinal chemists often search for small molecules that can bind to specific targets. A solution chosen when the target protein displays enzymatic activity, or the researchers have labeled ligands that can be used in displacement assays, is the use of large libraries of chemical compounds that can be screened individually in order to identify novel ligands. These highthroughput screening approaches can be expensive, both in terms of target protein requirements and costs in synthesizing the library, such as in chemical synthesis and the use of robotics. In this regard, the use of DNA fragments as amplifiable "bar-codes" for the identification of chemical compounds in a library represents an attractive avenue for the synthesis and screening of large combinatorial libraries