Dirk Trauer; Belinda E. Hetzler; Andrej Shemet
Synfacts, 2020, 16(07), 0850
https://doi.org/10.1055/s-0040-1707873

Abstract

DNA-barcoded chemical libraries are powerful tools in drug discovery and allow for the rapid screening of large compound numbers for biological target engagement. The authors showcased DNA-compatible cycloaddition methods that form sp3-rich, rigid, and diverse scaffolds that are ideally suited for library generation.