DNA-encoded chemical libraries: A tool for drug discovery and for chemical biology

Jörg Scheuermann; Dario Neri
ChemBioChem, 2010, 11(7), 931-7
https://doi.org/10.1002/cbic.201000066

Abstract

DNA decoder: The Collection of organic molecules, individually coupled to distinctive oligonucleatides, is generally referred to as "DNA-encoded chemical library". In full analogy to phage disply technology, these libraries can be panned on immobilized target protains and analyzed (before and after selection) by suitable "decoding" methods (for example, DNA-sequencing).

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