DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to NewDrugs

Richard A. Lerner; Sydney Brenner
Angew. Chem. Int. Ed. Engl., 2017, 56, 1164-1165
https://doi.org/10.1002/anie.201612143

Abstract

“… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA‐ encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high‐throughput screening centers …” Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.

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