DNA-encoded drug libraries come of age

Asher Mullard
Nat. Biotechnol., 2016, 34(5), 450-1
https://doi.org/10.1038/nbt0516-450b

Abstract

DiCE Molecules, a company with a new approach to DNA-encoded chemical libraries, signed a deal in March worth $2.3 billion with French pharma Sanofi. The Paris-based drugmaker will pay DiCE an initial $50 million to access DiCE’s ‘directed-evolution’ technology and up to $184 million in milestones per target. In January, Sanofi also inked a drug discovery deal with X-Chem, a biotech with a DNA-encoded drug discovery platform, based in Waltham, Massachusetts.

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