Francesco V. Reddavide; Michael Thompson; Luca Mannocci; Yixin Zhang
Aldrichimica Acta, 2019, 52, 3, 63
https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma-Aldrich/General_Information/2/acta-52-3-mk.pdf#page=63

Abstract

An urgent challenge in chemistry and biotechnology is to develop a routine, robust, and cost-effective method for the identification of molecules that specifically bind to a large variety of protein targets. In recent years, an elegant selection method for small-molecule drug discovery, DNA-encoded chemical library (DECL) technology, has been receiving much attention from the pharmaceutical and biotechnology industries. Here, we review the major recent developments in DECL technology, with a focus on the self-assembling dual-display format, which aims to combine the bio-inspired selection process with a fragmentbased approach to discover potent binders to protein targets.