Robert A. Goodnow; Christopher P. Davie
Annu. Rep. Med. Chem., 2017, 50, 1-15
https://doi.org/10.1016/bs.armc.2017.09.002

Abstract

In the 25 years since the first publication of the concept of encoded combinatorial library synthesis with sequences of DNA, DNA-encoded library technology (DELT) has become a widely accepted method for hit finding along with high-throughput screening. This method has been shown to be useful by the numerous, valuable hits that have been published as well as by the announcement of several drug development candidates that originated from DELT hits. Multiple methods exist for directing and encoding library synthesis, demonstrating the robust nature of this informational and functional platform. In its current, commonly practiced format, this method is in theory readily applicable to any hit finding problem for soluble protein targets. The robust nature of DNA binding and recognition properties is part of the continuous evolution of DNA-encoded and DNA-directed methods