Tuan Trinh; Pongphak Chidchob; Hassan S. Bazzi; Hanadi F. Sleiman
Chem. Commun., 2016, 52, 10914-10917
https://doi.org/10.1039/c6cc04970b

Abstract

We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.