Katarzyna Gorska; Kuo-Ting Huang; Olivier Chaloin; Nicolas Winssinger
Angew. Chem. Int. Ed. Engl., 2009, 48, 7695-7700
https://doi.org/10.1002/anie.200903328

Abstract

All under control: The programmability of hybridization has been utilized to generate a combinatorial library of structures that emulate the topologies of complex carbohydrates interacting with an antibody that shows broad‐spectrum activity against HIV. This simple method involves attaching oligosaccharides tagged with peptide nucleic acids onto DNA templates in a controlled manner (see schematic picture).