DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker

Katarzyna Gorska; Alex Manicardi; Sofia Barluenga; Nicolas Winssinger
Chem. Commun., 2011, 47, 4364-4366
https://doi.org/10.1039/C1CC10222B

Abstract

Nucleic acid templated reactions have attracted significant attention for nucleic acid sensing. Herein we report a general design which extends the potential of nucleic acid templated reactions to unleash the function of a broad diversity of small molecules such as a transcription factor agonist, a cytotoxic or a fluorophore.

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