Jörg Scheuermann; Dario Neri
Curr. Opin. Chem. Biol., 2015, 26, 99-103
https://doi.org/10.1016/j.cbpa.2015.02.021

Abstract

In contrast to single-pharmacophore DNA-encoded libraries, where only one chemical moiety is linked to DNA, dual-pharmacophore DNA-encoded chemical libraries feature the display of two independent small-molecules in close proximity. This, in principle, allows to explore adjacent epitopes on a pharmaceutical target of choice and hence the discovery of simultaneously binding pairs of fragments, by virtue of the chelate effect.