Takatoshi Yogo
Pharmacia, 2017, 3, 261
https://doi.org/10.14894/faruawpsj.53.3_261

Abstract

In the research and development of small molecule drugs, it is important to obtain good hit compounds that can expand the structure. DNA-encoded compound library technology (ELT) has a DNA tag. This is a technique in which a library of hundreds of millions of compounds is subjected to a binding test with a target protein in a mixture, and the binding compounds are identified through affinity selection, amplification of DNA tags by PCR, and DNA sequencing (Figure 1A). Has attracted attention as a hit compound identification technology in recent years because it enables high-speed screening of huge and diverse low-molecular weight compounds against target proteins. The case of GlaxoSmithKline (GSK) is introduced, and this paper introduces the research results based on the following documents.