Nicolas Probst; Rémy Lartia; Océane Théry; Mouâd Alami; Eric Defrancq; Samir Messaoudi
Chem. Eur. J., 2018, 24(8), 1795-1800
https://doi.org/10.1002/chem.201705371

Abstract

An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases