Gisele Nishiguchi; Sourav Das; Jason Ochoada; Heather Long; Richard E. Lee; Zoran Rankovic; Anang A. Shelat
Drug Discov. Today, 2021, 26(4), 1060-1069
https://doi.org/10.1016/j.drudis.2021.01.005

Abstract

The quality of lead compounds is a key factor for determining the success of chemical probe and drug discovery programs. Given that high-throughput screening (HTS) continues to be a dominant lead generation paradigm, access to high-quality screening libraries is crucial for such efforts in both industry and academia. Here, we discuss the strategy implemented a decade ago to build from scratch one of the largest compound collections in academia, containing ∼575 000 carefully annotated small molecules, and a recent multidisciplinary effort designed to further enhance the collection to meet our research demands for the next decade.