François Debaene; Julien A.Da Silva; Zbigniew Pianowski; Fernando J.Duran; Nicolas Winssinger
Tetrahedron, 2007, 63, 6577-6586
https://doi.org/10.1016/j.tet.2007.03.033

Abstract

Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes.