Yujin An; Juyeon Lee; Hyewon Seo; Seri Bae; Jihee Kang; Jieon Lee; Jinwoo Kim; Myung Hee Nam; Minsoo Song; Gil Tae Hwang
Org. Lett., 2023, 25(24), 4445-4450
https://doi.org/10.1021/acs.orglett.3c01366

Abstract

This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2-a]pyridin-3-amine derivatives using the Suzuki–Miyaura reaction, followed by a Groebke–Blackburn–Bienaymé (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology.