Asitha Adrian Abeywardane; Tushar Dattu Apsunde; Gianluca Nicolas Etienne; Alessia Gambardella; James Kevin Mainquist; Andrew J. Meyer; Brian Minie; Steven Paula; Dwayne A. L. Vickers; Ken Yamada; Docket Central
US20240183076A1
https://www.freepatentsonline.com/y2024/0183076.html

Abstract

The present disclosure generally relates to compositions, methods, sorters, systems, devices and uses for screening for bioactive substances in emulsion droplets. In some embodiments, the compositions are a continuous phase formulation for stable emulsions, In some embodiments, the methods are for preparing a monodisperse polyethylene glycol acrylamide (PEGA) co-polymer resin, or for preparing a core-shell bead. In some embodiments, the systems and devices include a sorter, comprising an inlet channel, first and second outlet channels meeting the inlet channel at a junction, and first and second electrodes proximate respective first and second sides of the junction sorter. In some embodiments, the systems and devices include a sorter, comprising a microwell array plate configured to host one microdroplet per microwell, a fluorescence microscope, an imager configured to automatically image assay droplets and identify desired droplets, and an automated microcapillary-based droplet sampling device configured to continuously deposit desired droplets to hit wells.