Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

Raphael M. Franzini; Angela Nauer; Jörg Scheuermann; Dario Neri
Chem. Commun., 2015, 51, 8014-8016
https://doi.org/10.1039/C5CC01230A

Abstract

Parallel affinity screening of a DNA-encoded chemical library against rat, bovine and human serum albumin allowed the identification of small-molecule ligands with distinctive binding specificities to the individual proteins.

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