Ayun Luo; Ziqi Zhang; Fanming Zeng; Xiuming Wang; Xue Zhao; Kexin Yang; Yun Jin Hu
Org. Lett., 2022, 24, 31, 5756–5761
https://doi.org/10.1021/acs.orglett.2c02237

Abstract

β-Lactam antibiotics are one of the most important antibacterial drug classes worldwide. This work will present the first prototype on-DNA β-lactam combinatorial library with novel structures and chemical space properties that would be significant for phenotypic screening to identify the next generation of antibiotics to combat the pervasive problem of bacterial resistance.