Ryosuke Ueki; Shinsuke Sando
MedChem. News, 2018, 28(2), 93-97
https://doi.org/10.14894/medchem.28.2_93

Abstract

DNA-encoded library (DEL) has attracted much attention as a promising approach for efficient ligand generation. Taking advantage of unique characteristics of DNA, DEL has realized drug discovery using a small molecule library with an unprecedented diversity. This review article summarizes the construction methods for DEL with a particular focus on chemical properties of DNA