Lijun Xue; Jiaqing Yu; Ying Zhong; Junyun Chen; Chao Li; Kexin Yang; Nicolas Duchemin; Yunjin Hu
Chem. Commun., 2024, 60, 6885-6888
https://doi.org/10.1039/d4cc02193b

Abstract

We here describe a visible-light photooxidation of sulfinate salts with common alkenes to yield β-hydroxy sulfones on DNA. This process demonstrates a broad substrate compatibility and achieves conversion rates ranging from moderate to excellent. Most importantly, it presents a straightforward, efficient, and metal-free approach for synthesizing Csp3-rich DNA-encoded libraries.