Yandan Bao; Minyan Xing; Naylor Matthew, Xiaohua Chen; Xuan Wang; Xiaojie Lu
Org. Lett., 2023, XXXX, XXX, XXX-XXX
https://doi.org/10.1021/acs.orglett.3c01817

Abstract

While DNA-encoded macrocyclic libraries have gained substantial attention and several hit compounds have been identified from DNA-encoded library technology, efficient on-DNA macrocyclic methods are also required to construct DNA-linked libraries with a high degree of cyclization and DNA integrity. In this paper, we reported a set of on-DNA methodologies, including the use of an OPA-mediated three-component cyclization with native handles of amino acids and photoredox chemistries. These chemistries proceed smoothly under mild conditions in good to excellent conversions, successfully generating novel isoindole, isoindoline, indazolone, and bicyclic scaffolds.