Multistep DNA‐Templated Reactions for the Synthesis of Functional Sequence Controlled Oligomers

Mireya L. McKee; Phillip J. Milnes; Jonathan Bath; Eugen Stulz; Andrew J. Turberfield; Rachel K. O'Reilly
Angew. Chem. Int. Engl., 2010, 49(43), 7948-7951
https://doi.org/10.1002/anie.201002721

Abstract

Biomimetic : A strand displacement mechanism was designed to permit DNA‐templated synthesis of functional oligomers of arbitrary length (see scheme). Key features of the mechanism are that successive coupling reactions take place in near‐identical environments and that purification is only necessary in the last synthesis step.

logo
logo