Yun Ding; Jennifer L. DeLorey; Matthew A. Clark
Bioconjugate Chem., 2016, 27, 11, 2597-2600
https://doi.org/10.1021/acs.bioconjchem.6b00541

Abstract

A novel Pd catalyst system, [(t-Bu)2P-(OH)]2PdCl2 (POPd) with the ligand sodium 2′-(dicyclohexylphosphino)-2,6-dimethoxy-[1,1′-biphenyl]-3-sulfonate, is reported. It effectively catalyzes the Suzuki-Miyaura coupling of challenging phenyl chlorides and pyrimidinyl chlorides that are covalently linked to a double-stranded DNA-template with various boronic acids/esters.