Gang Li; Wenlu Zheng; Ying Liu; Xiaoyu Li
Curr. Opin. Chem. Biol., 2015, 26, 25-33
https://doi.org/10.1016/j.cbpa.2015.01.004

Abstract

Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries.